منابع مشابه
Combinatorial binding of transcription factors in the pluripotency control regions of the genome.
The pluripotency control regions (PluCRs) are defined as genomic regions that are bound by POU5F1, SOX2, and NANOG in vivo. We utilized a high-throughput binding assay to record more than 270,000 different DNA/protein binding measurements along incrementally tiled windows of DNA within these PluCRs. This high-resolution binding map is then used to systematically define the context of POU factor...
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In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-r...
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Pluripotent cells have unique properties of self-renewal while maintaining developmental potential to differentiate into all three germ layers. By definition, pluripo-tent cells have no predetermined lineage program, thereby forming the fundamental basis of enquiry and experimental investigations to understand cell fate decisions. Molecular and cellular insights into human pluripotent stem cell...
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Here, issues connected with characteristic stochastic practices are considered. In the first part, the plausibility of covering the arrangements of an improvement issue on subjective subgraphs is studied. The impulse for this strategy is a state where an advancement issue must be settled as often as possible for discretionary illustrations. Then, a preprocessing stage is considered that would q...
متن کاملPluripotency and nuclear reprogramming.
Embryonic stem cells are promising donor cell sources for cell transplantation therapy, which may in the future be used to treat various diseases and injuries. However, as is the case for organ transplantation, immune rejection after transplantation is a potential problem with this type of therapy. Moreover, the use of human embryos presents serious ethical difficulties. These issues may be ove...
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ژورنال
عنوان ژورنال: Nature Reports Stem Cells
سال: 2009
ISSN: 1754-8705
DOI: 10.1038/stemcells.2009.12